Interactions

Understanding enzyme or transporter-based drug interactions

22 May 2024Many interactions are due to inhibition or induction of metabolising enzymes or drug transporters. Enzyme, transporter, and drug half-lives dictate duration.

Using folic acid and phenytoin safely

12 April 2024Folic acid interacts with phenytoin and can reduce phenytoin blood levels. Concomitant use is possible with careful management of the interaction.

Herbal interactions: resources to support answering questions

28 March 2024Suggested resources to help healthcare professionals find information to answer questions about herbal interactions.

Questions to ask when reviewing herbal medicines and interactions

28 March 2024Information should be gathered about the patient and herbal medicine to enable risk assessment and decision making on the interaction.

Understanding complementary medicines

28 March 2024Points to consider when advising on the use of complementary medicines.

Understanding drug interactions

15 January 2024This article discusses different mechanisms of drug interactions. We link to other SPS articles to help support decision making.

Managing interactions with direct oral anticoagulants (DOACs)

5 January 2024Interactions with apixaban, dabigatran, edoxaban or rivaroxaban can result in increased risks of a bleed or thrombosis. We advise on management options.

Understanding direct oral anticoagulant (DOAC) interactions

5 January 2024It is important to understand the risks, mechanisms of interactions and actions to take when prescribing medicines with DOACs.

Managing interactions with methotrexate

28 December 2023Guidance on frequently asked questions on medicine interactions with low dose methotrexate.

Managing interactions between macrolides and statins

24 November 2023The use of statins can be continued with azithromycin. However, the interaction risks need to be managed if clarithromycin or erythromycin are required.

SPS - Specialist Pharmacy Service

NHS