Licensed for intrathecal use
Products licensed for intrathecal use are the first line option and should be used wherever suitable.
There are currently no known diamorphine products licensed for intrathecal administration.
Not licensed for intrathecal use, limited information available
Products with partial information that are not licensed for intrathecal administration can still sometimes be used. Refer to the advice in our article and complete a risk assessment to enable you to interpret the details below and choose an appropriate product.
Accord
Strength
Excipients
No information
Osmolarity
~24 mOsmol/L
pH
5.0 – 5.9
Endotoxin content
No information
Strength
Excipients
No information
Osmolarity
~45 mOsmol/L
pH
5.2 – 5.5
Endotoxin content
No information
Strength
Excipients
No information
Osmolarity
~118 mOsmol/L
pH
5.0 – 5.2
Endotoxin content
No information
Strength
Excipients
No information
Osmolarity
~185 mOsmol/L
pH
4.2 – 4.4
Endotoxin content
No information
Strength
Excipients
No information
Osmolarity
~575 mOsmol/L
pH
4.6 – 4.8
Endotoxin content
No information
Ennogen
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~24 mOsmol/L
pH
5.0 – 5.9
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~45 mOsmol/L
pH
5.2 – 5.5
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~118 mOsmol/L
pH
5.0 – 5.2
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~185 mOsmol/L
pH
4.2 – 4.4
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~575 mOsmol/L
pH
4.6 – 4.8
Endotoxin content
No information
Wockhardt
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~24 mOsmol/L
pH
5.0 – 5.9
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~45 mOsmol/L
pH
5.2 – 5.5
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~118 mOsmol/L
pH
5.0 – 5.2
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~185 mOsmol/L
pH
4.2 – 4.4
Endotoxin content
No information
Strength
Excipients
Water for injection (not detectable in the finished product)
Osmolarity
~575 mOsmol/L
pH
4.6 – 4.8
Endotoxin content
No information
Unlicensed ‘Special’, specified for intrathecal use
Unlicensed medicines that are manufactured in MHRA-licensed Specials Manufacturing Units, at the request of an authorised healthcare professional specifically for intrathecal use.
Preston Pharmaceuticals – Royal Preston Hospital
Strength
500 micrograms in 0.5mL PFS
Queen Alexandra Hospital, Portsmouth
Strength
1mg/mL in 1mL PFS
Royal Hospitals, Belfast – Victoria Pharmaceuticals
Strength
500 micrograms/mL in 1mL PFS
Royal Liverpool Hospitals Foundation Trust
Strength
300 micrograms in 0.3mL PFS
Stepping Hill Hospital – Stockport Pharmaceuticals
Strength
1mg/mL in 1mL PFS
Wirral Hospital aseptic manufacturing unit
Strength
300 micrograms in 0.5mL PFS
500 micrograms in 0.5mL PFS
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