Cautions and contraindications

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Cautions and contraindications

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Medications for treating CRS and ICANS

2 October 2026Guidance on which medications to use when treating CRS and ICANS.

Diagnosis and management of ICANS

2 October 2026Guidance on the management of immune effector cell-associated neurotoxicity syndrome (ICANS) in adults receiving licensed CAR-T cell products.

Diagnosis and management of cytokine release syndrome (CRS)

2 October 2026Guidance on the management of CRS in adult patients receiving licensed CAR-T cell products.

Understanding acute CAR-T cell therapy toxicities in adults

2 October 2026Guidance on the management of acute side effects in adults receiving licensed CAR-T cell therapy products.

Choosing medicines in sulfonamide hypersensitivity

9 September 2026People allergic to one sulfonamide antibiotic should avoid other sulfonamide antibiotics. We advise on prescribing non-antibiotic sulfonamides in this situation

Commonly used medicines associated with QT interval prolongation

27 August 2026Examples of medicines known to prolong the QT interval. Medicines are grouped by therapeutic class and are not an exhaustive list.

Choosing an antidepressant for people with epilepsy

26 March 2026Selective serotonin reuptake inhibitors (SSRIs) are the preferred antidepressant in people with epilepsy. We give considerations when selecting antidepressants.

Assessing the clinical impact of sodium content in medicines

17 March 2026Sodium content in medicines can be a concern, especially for those on salt-restricted diets. Awareness is important for safe prescribing and patient management

Supportive medicines guidance for adults on CAR-T cell therapy

11 February 2026This document provides expert clinical pharmacy guidance on supportive medicines in order to facilitate the treatment of complex CAR-T Cell Therapy patients.

Medication restrictions for CAR-T cell therapy

11 February 2026CAR-T Therapy requires some medicines to be restricted, this guidance provides details and recommended wash-out periods for restricted medicines.